Although this collection of articles is not formally a commentary on Elizabeth Anscombe's famous article of the same title, in which she criticized the moral philosophy prevalent in 1958, a number of the contributors consider Anscombe's work as a starting point. The collection can be interpreted as a demonstration of the extent to which moral philosophers have since attempted to respond to Anscombe's challenge, and to develop an approach to their subject which is neither based on divine law nor permissive of the impermissible.